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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
VINCRISTINE-INDUCED BILATERAL VOCAL CORD PARALYSIS IN A CHILD WITH RHABDOMYOSARCOMA
Author
Muhammad Matloob Alam*, Ahmed Raza Iftikhar, Zehra Fadoo
Email
dr.matloobalam@hotmail.com
keyword
Rhabdomyosarcoma, Neuropathy, Vincristine, Vocal cord palsy.
Abstract
Vincristine-induced vocal cord paralysis is a rare but potentially dangerous condition. Its neurotoxicity is dose limiting and resolves spontaneously upon withdrawal of the vincristine in most of the cases. We describe a child with rhabdomyosarcoma who developed bilateral vocal cord paralysis causing progressive stridor during treatment with vincristine. A high index of suspicion of vincristine-induced vocal cord palsy is needed in a child on chemotherapy with new onset stridor with prompt otolaryngology consultation. Concomitant use of azoles possibly enhance the neurotoxicity effect of vincristine thus should be used with caution.
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