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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
IN-VIVO ANTIDIABETIC ACTIVITY OF ETHANOLIC FLOWER EXTRACT MELIA AZEDARACH L
Author
Asokan BR1, Bharani Rajkumar2, Balamuruganvelu S3 and Jaikumar S4*
Email
sengt@rediffmail.com
keyword
Melia Azedarach L, Streptozocin, Antidiabetic activity, Neem.
Abstract
Throughout the world there are several medicinal plants with proven beneficial claims towards different pathological conditions. Medicinal plants constitute an important source of potential therapeutic agents for diabetes. Melia Azedarach L is closer the family of neem, has a potential biological activity as Azadirachta indica. This study aimed to determine the antihyperglycemic effect of ethanolic flower extract of Melia Azedarach L (200mg/kg) against Streptozocin (STZ, 60mg/kg, i.p) induced diabetes in rats. Glibenclamide (0.25mg/kg) was used as reference control. The test drugs were administered for 15 days once daily. The mean blood sugar levels were determined at different time intervals. The result showed that, there was a significant reduction in the blood sugar after the administration of ethanolic flower extract of Melia Azedarach L in STZ induced diabetic animals. From the result it was concluded that, ethanolic flower extract of Melia Azedarach L possess antidiabetic activity against STZ induced diabetic in rats.
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