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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
RESULTS OF PRENATAL TESTS IN CASES AFTER ASSISTED REPRODUCTIVE TECHNOLOGIES
Author
Danielius Serapinas
Email
dserapinas@gmail.com
keyword
In vitro fertilization, Chromosomal anomalies, Prenatal diagnostics.
Abstract
In vitro fertilisation (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided in developed countries. However recent scientific publications suggest that there is an elevated risk of major structural malformations, imprinting defects and such syndromes as Prader-Willy, Angelman, Wiedeman-Beckwith. The aim of the study was to analyse if ART are associated with increased risk of genotoxicy for chromosomal nondisjunction in meiosis. Study included analysis of 50 families that prenatally were diagnosed chromosomal anomalies (Down, Turner, Klinefelter, Edwards, Patau syndrome). And control group included 70 families with healthy children. The results of present study showed, that in chromosomal anomalies group three cases of children with chromosomal anomalies were conceived after ART. In control group all healthy children were conceived naturally (p<0.05). The study also showed a statistically significant relationship between: older age of the woman (> 35 years old) and the occurrence of trisomy (p<0.05). The number of observed pathological cases is not so big to make exact conclusions, but results of present study supports hypothesis, that ART are associated with greater risk of chromosomal anomalies in conceived children
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