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American Journal of Oral Medicine and Radiology

Volume 5, Issue 2, 2018
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
BIOLOGY OF TUMOR MICROENVIRONMENT: A REVIEW
Author
Ravi Kumar Pujari1* and Vidya N2
Email
raveepujari@yahoo.com
keyword
Tumor microenvironment, Optimal clinical outcomes.
Abstract
Cancer is a systemic disease, and it is not a solo production but rather an ensemble performance. The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development of frontline interventions in clinical oncology. As benign cells in TME niches actively modulate response of cancer cells to a broad range of standard chemotherapies and targeted agents, cancer-oriented therapeutics should be combined with TME-targeting treatments to achieve optimal clinical outcomes.
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