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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
QTC INTERVAL PROLONGATION AND ITS EFFECT ON OUTCOME OF THE SEPTIC ICU PATIENTS
Author
Pradeep M Venkategowda1, Manimala Rao2*, Siva Kanth2, Swathi2, Yogesh R Harde2, Mithilesh K Raut2, Dnyaneshwar P Mutkule2, Surya P Yarramalle2
Email
manimalarao@hotmail.com
keyword
QTc Prolongation, Torsade de pointes, Sepsis, Arrhythmias, Mortality, After depolarization.
Abstract
Aim to correlate QTc prolongation and its effects on APACHE score, SOFA score, length of stay and outcome of the septic ICU patients. In a prospective observational study conducted in single tertiary hospital between March-December 2013. Patients with sepsis admitted to our ICU were included. These septic patients were divided into two groups, one group having normal QTc interval on ECG (electrocardiogram) and other group with prolonged QTc interval. The APACHE score, SOFA score, ICU duration of stay and associated mortality has been observed during their ICU stay. Our study included 155 patients with sepsis. Among these patients, 129 patients had normal where as 26 patients had prolonged QTc interval on 12 lead ECG. The incidence of QTc prolongation was 16.7% (26/155). The APACHE (8.67 ± 5.53 Vs 13.46 ± 5.88), SOFA (2.35 ± 2.08 Vs 5.42 ± 3.26) and ICU duration of stay (92.92 ± 19.84 Vs 157.26 ± 52.53 hours) were statistically significant (p<0.05) in patients with prolonged QTc interval whereas the ICU mortality (14 deaths / 129 patients Vs 5 deaths / 26 patients) was not statistically significant. Drug induced QTc prolongation was common risk factor in our study. Prolonged QTc interval can be considered as one of the severity and morbidity indicator in critically ill septic patients with other established scores like APACHE-II and SOFA. Older age and female sex has been associated with high incidence of QTc interval prolongation.
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