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Der Pharmacologia Sinica

Volume 1, Issue 1, 2014
Mcmed International
Der Pharmacologia Sinica
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editordps@mcmed.us
Journal Home page
http://mcmed.us/journal/dps
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Abstract
Title
EFFECT OF NICOTINE ON HEMATOLOGY, LIPID PROFILE AND LIVER ENZYMES IN ADULT MALE MICE (MUS MUSCULUS)
Author
Saima Sharif*, Tasnim Farasat, Nargis Fatima, Ayesha Farooq, Shagufta Naz, Sabiha Fazal
Email
ssharif1978@yahoo.com
keyword
Nicotine administration, Hematological parameters, Lipid profile, Liver enzymes, Mice.
Abstract
The study was designed to observe effects of nicotine on various hematological parameters, lipid and hepatic profile of adult male mice. Mice (n=60) were divided into two groups; control and experimental. Subcutaneous injections of 1 mg/kg body weight of nicotine were given to the experimental (n= 40) and saline solution to the control (n= 20) group. Hematological parameters were assessed by using hematological analyzer and biochemical analyses were done by Chemistry analyzer. The WBCs, PLT, HCT, MCV, Cholesterol, triglycerides and LDL-C were found significantly higher (p<0.05) in an experimental group by comparing with control group while the significant decrease was observed in RBCs count, Hgb, MCH and MCHC, HDL-C and HDL-C/LDL-C raio in the experimental group. Significant increase in the liver enzymes ALT, AST and ALP were observed, whereas total bilirubin (mg/dl), albumin and total protein showed significant decrease in the experimental group. It is concluded that nicotine administration in mice resulted in deleterious effects on various hematological parameters and biochemical parameters.
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