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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
MODULATORY EFFECT OF LOTUS (Nelumbo nucifera) IN ALCOHOL INDUCED LIVER INJURY IN ALBINO RATS
Author
Vinodhini Rajamanickam*
Email
sivaniswetha@yahoo.com
keyword
Nelumbo nucifera, alcohol toxicity, hepatoprotection, antioxidant.
Abstract
Liver injury and cirrhosis are related to prolonged alcohol consumption. Acute ethanol administration causes fatty liver and hyper-trigylceridemia. The objective of the present study is to elucidate the hepatoprotective and antioxidant properties of N. nucifera (bwtp.o) against 30% alcohol intoxication in albino rats. Biochemical protocols were performed in liver tissue homogenates for TBARS, SOD, Catalase GSH, Vitamin C and E, iron, copper, cytochrome P450 and Na+/K+/ATPase. The results showed a significant reduction in SOD, Catalase and GSH of alcohol intoxicated groups. Ratsfed with crude powder of N. nucifera (1gm/Kg bwtp.o) for 21 days as a treatment period significantly increased the enzymes compared to the control groups. The results suggest that N. nucifera exhibit most significant (p < 0.001) hepatoprotective and superior antioxidant activity.
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