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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME WITH COMPLEX KARYOTYPES: REPORT OF TWO CASES - EXPERIENCE AT A TERTIARY CARE HOSPITAL
Author
Rigvardhan, Kavita Chauhan, Jyoti Kotwal, Prosenjit Ganguli, Ajay Sharma, MD, Jasjit Singh
Email
atuljyot@hotmail.com
keyword
Myeloid leukemia associated with Down syndrome, Complex karyotype, Flow cytometry.
Abstract
Down syndrome is the most common chromosomal abnormality in the live newborn. It is associated with increased incidence of malignancies. Approximately, 1 in 100-200 DS children develop acute leukemia with approximately equal numbers of acute lymphoid and myeloid leukemias. Down associated myeloid leukemia is usually megakaryoblastic type and exhibit characteristic flow cytometry pattern. They express CD45, CD34, CD33, CD38, CD36, CD56, HLA-DR, CD7, and at least one of the megakaryocytic markers CD41, CD42a, or CD61. Less frequently, the blasts express CD4, CD13, CD11b, CD265 (glycophorin A), orCD15. These blasts do not express the lymphoid markers such as CD3, CD5, CD19, and CD20.Here we wish to present two cases of myeloid leukemia associated Down syndrome with complex karyotypes. Of these two cases, one case was suspected to have Down syndrome due to characteristic flow cytometry pattern and was later confirmed on karyotyping.
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