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European Journal of Environmental Ecology

Volume 10, Issue 1, 2023
Mcmed International
European Journal of Environmental Ecology
Issn
XXX-XXXX (Print), 2393 - 9672 (Online)
Frequency
bi-annual
Email
editorejee@mcmed.us
Journal Home page
http://mcmed.us/about/ejee
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Abstract
Title
HOMALOMENA AROMATICA: AN ETHNOMEDICINAL PLANT, CAN BE A POTENTIAL SOURCE OF ANTIMICROBIAL DRUG DEVELOPMENT
Author
Amritesh C. Shukla1*, Fanai Lalsangluaii1, Binnu Singh1, Awadhesh Kumar1, H. Lalramnghinglova2 and Anupam Dikshit3
Email
amriteshmzu@gmail.com
keyword
Ethno medicinal plant(s), pathogenic fungi, essential oil, antimicrobial activity.
Abstract
The genera Homalomena belongs to the family Araceae of the group Monocotyledon. There are about 140 spices in tropical Asia and South America; two species in India; one in Mizoram, i.e., Homalomena aromatica Schott. The plant is very popular among the Mizo-tribal communities. The boiled petiole is used as vegetable, rhizome as aromatic stimulant, powdered rhizome as gun-powder, burnt smoke of rhizome as mosquito repellent and infusion of the plant for easy labor. The juice of whole plant is used as lotion in skin diseases. Besides these, the plant contains strong antimicrobial activity. The minimum cidal concentration (MCC) of the oil against some common human pathogenic fungi was found to be 1.2 to 1.8 μl/ml, which contains heavy inoculums density. The oils toxicity o persists up to 80 C and also autoclavable, with a broad fungi toxic spectrum. The pure oil kills the test pathogenic fungi just within a minute; however, its MCC takes 5.30 to 6.30 hrs to kill all the test fungi. Besides this, while comparing the MECs of the oil with some synthetic antifungal drugs, the toxicity of the oil shows an edge over the synthetics- Dactrine, Nizaral, Tenaderm and Batrafine. Relationship of the dermatophytes to the toxicity of the oil vis-a vis phylogeny using molecular data of the pathogens have also been discussed. Further, during pre-clinical investigations, the efficacy of oil contains 60-80% cure of the skin diseases. Based on these findings as well as after detailed in vitro, in vivo, clinical as well as multi-central clinical investigations; formulations can be transferred to the pharmaceutical companies.
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