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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
STUDY OF SEVOFLURANE IN INDUCING OXIDATIVE STRESS IN PATIENTS UNDERGOING GENERAL ANESTHESIA
Author
T. Ananta Venkata Raman* and C. Chandraprakash
Email
anantavraman@gmail.com
keyword
General anaesthesia, Sevoflurane, Free radical, Reactive oxygen species, Antioxidants.
Abstract
Sevoflurane is frequently used for general anaesthesia and earlier many studies have shown that this anaesthetic drug has an impact on oxidative stress and antioxidative defence mechanisms. This study was planned to evaluate the effects of sevoflurane, in general anaesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy and appendectomy. A total of 12 patients between 29 and 47 years with planned laparoscopic cholecystectomy and appendectomy under general anaesthetic were selected for this study. Same numbers of normal control persons were recruited in this study. For inducing and maintenance of general anaesthesia experimental group was ventilated with 2% sevoflurane. One hour before induction of general anaesthesia and one hour after the surgery venous blood samples were taken to evaluate the levels of lipid profile, total oxidants and antioxidants. The general physical characteristics of the subject were also recorded with simple questionnaire were matched with control group. In the post-anaesthesia period we observed that sevoflurane induced general anaesthesia increased total oxidants level and antioxidants by a statistically significant level, this indicates that sevoflurane induced general anaesthesia increases formation o free radicals and thus cause an oxidative stress in subject.
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