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American Journal of Advanced Medical & Surgical Research

Volume 2, Issue 1, 2016
Mcmed International
American Journal of Advanced Medical & Surgical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorajamsr@mcmed.us
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Abstract
Title
COMPARATIVE STUDY OF FRESH VERSUS OLD STORED BLOOD IN THE PRIMING OF EXTRACORPOREAL CIRCUIT IN CARDIOPULMONARY BYPASS FOR PEDIATRIC PATIENTS
Author
Pankaj Garg1*, Amber Malhotra2, Pranav Sharma3, Arvind Kumar Bishnoi3, Atul Solanki4, Nikunj Vaidya5, Pratik Shah6
Email
pnkjgarg@yahoo.com
keyword
Packed red blood cells, Cardiopulmonary bypass, Pediatric cardiac surgery.
Abstract
We aim to evaluate the metabolic effects of fresh (≤7 days) versus old (>7 days) packed red blood cells (PRBCs) added to the priming solutions of pediatric patients undergoing cardiac surgery. Forty consecutive pediatric cardiac patients were divided into 2 groups. In group 1 fresh (≤7 days old) PRBCs were added to the priming solution, while in group 2 old (>7 days old) PRBCs were added. In each group, blood samples were drawn from the PRBCs on arrival, after addition to the priming solution, after 10 minutes of prime circulation, after 30 minutes of beginning of cardiopulmonary bypass (CPB) and on patient’s arrival to the pediatric intensive care unit (PICU). The levels of potassium, glucose, and the acid-base balance were assessed. There was a linear increase in potassium levels in packed red blood cell samples with increasing age of PRBCs, ranging from 5.5 to 17.8 mEq/L. Significant differences in the concentrations of potassium, glucose, and the acid-base balance were found when comparing old and fresh PRBCs in samples taken during the PRBCs and early prime time. Those differences resolved after 10 minutes of reconstitution of the priming solution. The age of the PRBCs had no effect on the samples taken during bypass and those taken in the pediatric intensive care unit. The significantly higher concentration of potassium and lower pH in old stored PRBCs has a minimal effect on the final constitution of priming solution before and during cardiopulmonary bypass in children undergoing corrective cardiac surgery.
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