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Singapore Journal of Pharmaceutical Research

Volume 2, Issue 1, 2015
Mcmed International
Singapore Journal of Pharmaceutical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorsjpr@mcmed.us
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Abstract
Title
PRE-EMPTIVE ANALGESIA; SALVAGE FOR THE PATIENTS: AN OVERVIEW
Author
Neerjesh P1, Dharti N2, Richa Wadhawan3, Gaurav Solanki 4
Email
richawadhawan@gmail.com
keyword
Pre emptive analgesia, Central sensitization, acute pain, chronic pain.
Abstract
Pain from surgical procedures occurs as a consequence of tissue trauma and may result in physical, cognitive, and emotional discomfort. Almost a century ago, researchers first described a possible relationship between intraoperative tissue damage and an intensifica-tion of acute pain and long-term postoperative pain, now referred to as central sensitization. Nociception activation is mediated by chemicals that are released in response to cellular or tissue damage. Pre-emptive analgesia is an important concept in understanding treatment strategies for postoperative analgesia. Pre-emptive analgesia focuses on postoperative pain control and the prevention of central sensitization and chronic neuropathic pain by providing analgesia administered preoperatively but not after surgical incision. Additional research in pre-emptive analgesia is warranted to better determine good outcome measurements and a better appreciation with regard to treatment optimization.
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