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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
PROPHYLACTIC TOTAL GASTRECTOMY (PTG) FOR HEREDITARY DIFFUSE GASTRIC CANCER (HDGC): CASE REPORT OF A GERMAN FAMILY- TREATMENT OPTION, RISKS AND COMPLICATIONS
Author
Khalid Al-Shareef
Email
drkhash93@hotmail.com
keyword
Prophylactic total gastrectomy, Hereditary diffuse gastric cancer and Curative surgery.
Abstract
Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome specifically associated with germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell–cell adhesion molecule, E-cadherin. Diagnosis is often difficult, as there is currently no good screening test for DGC, especially endoscopy. , it is nowadays commonly recommended, that prophylactic total gastrectomy (PTG) is the standard management of choice for germline E-cadherin gene mutation carriers. Four sisters aged between 54 and 58 years presented in our outpatients department with the genetic determined CDH1 gene mutation for further consultation. The genetic analysis was performed because their mother died at the age of 77 from gastric cancer, and their brother had already died from gastric cancer. Recommendations were prophylactic gastrectomy and all patients should undergo investigation for lobular breast cancer (LBC) (Mamogaram MRI,U\S, tumor marker CA15.3) and a Colonoscopy was recommended every 3-5 years from 40 years old age. Pre-operatively, no contraindications for the operations or evidences of other tumor localization so, patients were scheduled for the operations. Post-operatively, patients were discharged in good condition and histopathology resected stomach with regional lymph nodes of small and large were Tumor-free for all patients. Conclusively, hereditary gastric cancer is a rare disease. A reliable method for the detection of early stages or precursors of gastric cancer is not yet available. Curative surgery (PTG) can be performed at an early stage with a low rate of serious complications.
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