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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
CYTOKERATIN POSITIVE FIBROBLASTIC RETICULUM CELL SARCOMA IN A PATIENT WITH GLOMERULONEPHRITIS: ACCIDENTAL OR TRUE ASSOCIATION
Author
David Bakiratharajan, Nevitha Athikari*, Tanuja Shet
Email
tanujashet5@gmail.com
keyword
Lymph node, Dendritic tumour, Autoimmune diseases.
Abstract
Tumours of accessory reticulum cells are rare neoplasms arising mostly in lymph nodal areas. Cytokeratin positive Fibroblastic Reticulum Cell tumour is one such variety which has been reported very rarely in literature. Fibroblastic Reticular Cells (FRC’s) are cytokeratin positive Interstitial Reticulum Cells (CIRC’s) and a tumour derived from these cells expresses cytokeratin strongly mimicking metastases from a carcinoma. We report a 30 year old woman who presented with chronic glomerulonephritis and worsening of symptoms since a year with the appearance of an inguinal nodal mass. The node showed a spindle cell tumour with expression of cytokeratin that initially gave rise to suspicion of metastases, but as there was no primary detected, the tumour was excised. The lesion was subsequently recognized as a cytokeratin expressing fibroblastic reticulum cell sarcoma. The excision of the tumour resulted in improvement of renal function tests but the patient refused local radiotherapy and since last 9 months she is alive with no disease. Thus we speculate possible causes for the improved condition of patient and the pointers to the accurate histologic diagnosis of this rare entity.
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