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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
STUDY OF CYP2A6 GENE POLYMORPHISM AMONG BETEL QUID CHEWERS OF EASTERN AND NORTH – EASTERN INDIA
Author
1Adhikari Aniket and 2De Madhusnata
Email
aniket_adhikari@rediffmail.com
keyword
Oral cancer, Betel quid, CYP2A6 polymorphism.
Abstract
Oral cancer is most common cancer in males and third most common in females, one of the main causative agents being use of chewing betel quid (BQ). Areca nut (Areca catechu), a major component of BQ, contains certain alkaloids that give rise to nitrosamines. CYP2A6 genetic polymorphism was studied among the Eastern and North eastern Indian population. In this present study subjects were screened from Department of E.N.T. & Oral and Maxillofacial surgery of RKMSP hospital, Kolkata and different areas of Eastern and North Eastern states of India. Polymorphism of CYP2A6 gene was studied from EDTA blood. Some of the cases had more than one addiction. It has been found that most of the subjects had betel quid chewing habit. Early metabolizers are susceptible to oral cancer where as in case of poor metabolizers chances are less. Betel quid has an immense role in changing the oral pathology and developing oral cancer.
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