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International Journal of Advances In Case Reports

Volume 11, Issue 1, 2024
Mcmed International
International Journal of Advances In Case Reports
Issn
XXX-XXXX (Print), 2349 - 8005 (Online)
Frequency
bi-annual
Email
editorijacr@mcmed.us
Journal Home page
http://mcmed.us/about/ijacr
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Abstract
Title
A COMPARATIVE STUDY OF EFFICACY OF NIFEDIPINE, TAMSULOSIN AND THEIR COMBINATION FOR SPONTANEOUS EXPULSION OF DISTAL URETERIC STONES: AN INSTITUTIONAL STUDY
Author
1Pankaj Gupta, 1Sanjay Dosar, *2Dilip Chaurasia and 3Anil Kumar Saroj
Email
dilipchaurasia@yahoo.com
keyword
Nifedipine, Tamsulosin, Ureteric Stone.
Abstract
Purpose of study: In modern era we are going from open surgery to minimal invasive surgery and non invasive treatment options for distal ureteric stones. Medical expulsive therapy can be a better option. The results of wide spread clinical trials with selective α1A antagonist like tamsulosin and calcium channel blockers like Nifedipine is promising. This study was conducted to compare the efficacy of calcium channel blocker (Nifedipine) and α-1 receptor antagonist (Tamsulosin) alone and both in combination for the spontaneous expulsion of distal ureteric stones in relation to expulsion rate, expulsion time, analgesic use, need for hospitalization and other modalities of treatment. Material and Method: A total 58 symptomatic patients of distal ureteric calculi of less than 10 mm were randomly allocated to home treatment with Tamsulosin, Nifedipine and combination of both drugs (group 1 to 3 respectively). Each group was given Diclofenac (50 mg) twice daily and on demand. The primary end point was expulsion rate and secondary end points were expulsion time, analgesic use, need for hospitalization and other modalities of treatment. Conclusion: In our study Tamsulosin alone was found very effective for distal ureteric stone expulsion. Combination of both Tamsulosin and Nifedipine offered no added advantage and increases the cost of therapy.
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