TELL : +91 0 99 08 87 07 06

 Mcmed International ®: Largest Journal Publication in world

European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
Recommend to
A Friend  | A librarian
Purchase
Purchase Issue
Abstract
Title
INFLUENCE OF REPEATED ADMINISTRATION OF SERTRALINE ON THE ANTIDIABETIC ACTIVITY OF PIOGLITAZONE IN DIABETIC RATS
Author
Prashant Baganal 1, Suresh Janadri*2 Rajendra Sandur 3, Veerana Goud 4 and Ramachandra Setty 5
Email
sureshjanadri@gmail.com
keyword
Drug interaction, Sertraline, Pioglitazone, GOD-POD method
Abstract
The present study was carried out the repeated administration of sertraline on the antidiabetic activity of pioglitazone in alloxan induced diabetic rats. The blood was withdrawn from the retro-orbital plexuses of pioglitazone treated rats at different time intervals at 0 hr, 1, 2, 4, 8, 12, 18, 24 hour before and after administration of sertraline. The blood glucose was estimated by GOD-POD enzymatic method using semi-autoanalyzer and data are expressed in mg/dl. The results indicate sertraline increases the onset, peak effect and duration action of pioglitazone in diabetic rats during simultaneous administration of these drugs. In conclusion the dose and frequency of administration of sertraline and pioglitazone should be adjusted while administrating concomitantly.
Download Broucher
Back to Top >>>>