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Singapore Journal of Pharmaceutical Research

Volume 2, Issue 1, 2015
Mcmed International
Singapore Journal of Pharmaceutical Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorsjpr@mcmed.us
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Abstract
Title
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF OZCARBAZEPINE BY USING VARIOUS POLYMERS
Author
Brahmaiah Bonthagarala*, Prasanna Kumar Desu, Sreekanth Nama, Donthiboina Sudarshan
Email
brahmaiahmph@gmail.com
keyword
Ozcarbazepine, HPMC E50LV, Sustained Release, Eudragit RSPO.
Abstract
The objective of this study is to design and evaluate sustained release matrix tablets of Ozcarbazepine. The effects of various viscosity grades of Eudragit RSPO and HPMC E50LV on the release of Ozcarbazepine have been evaluated. Tablets were evaluated for physical and chemical parameters such as Hardness, Friability, Thickness, Weight variation, Drug content uniformity and in vitro release. All batches are complied physical and chemical parameters within the U.S.P limit. The amounts of Ozcarbazepine at different time intervals were estimated by UV Spectrophotometer method. In vitro release profile of Ozcarbazepine from combination of Eudragit RSPO and HPMC E50LV polymers (F8) showed that 100% of the drug was released at the end of 24 hr which is considered as optimized formulation. The tablets showed no significant change either in physical appearance or in dissolution pattern after storing at room temperature, 40° c and 75% RH and 2-8°c for three months. The drug release data fit well to Higuchi, Peppas and Korsemeyer equation. The drug release was found to diffusion and little extent by erosion.
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