International Journal of Advances In Case Reports

BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN FROM VARIOUS BODY FLUIDS OF PATIENTS ATTENDING RAMA MEDICAL COLLEGE HOSPITAL, KANPUR

Sujatha R1, Nidhi Pal2, Arunagiri D3, Narendran D4

drsujatha152@gmail.com

Body fluids, antibiotic sensitivity, E.coli, S.aureus.

Sterile body fluids like pleural, peritoneal, cerebrospinal, synovial or pericardial fluids can be invaded and infected with microorganisms, especially bacteria which may result in severe morbidity and mortality. This study was undertaken to determine the antibiotic sensitivity pattern and their etiological agents of various bacterial infections in the body fluids. A total of 100 samples from patients who visited Rama Medical College Hospital & research center, Kanpur were analysed for bacteriological culture and antibiotic sensitivity over a period of one year. Clinical specimens (body fluids) were processed for bacterial culture according to the standard procedures and antimicrobial susceptibility test for isolated organisms was done using agar disk diffusion method. In 100 samples of various body fluids culture was positive in 31%. . Growth was most commonly seen in Pleural fluid (21%), peritoneal fluid (6%) and CSF (4%) respectively. There were no growth from synovial fluid and pericardial fluid. The most predominant isolates were E.coli (38.7%), S.aureus (22.5%), S.pneumoniae (19.35%), Klebsiella spp. (12.9%) and Pseudomonas spp. (6.45%). E.coli, Klebsiella spp. and Pseudomonas are most commonly sensitive to Imipenem, Meropenem, Colistin, Polymixin B; S.aureus to, clindamycin, Linezolid, Teicoplanin and Vancomycin; Pseudomonas to Piperacillin + Tazobactum. Drug resistance was high in the isolated microorganisms. The clinical implication warrant further study of antibiotic sensitivity in the treatment of above infected body fluids. It is necessary to treat the body fluid infections by the empirical use of antimicrobial drugs as soon as possible to reduce the morbidity and mortality, this is based on the knowledge of epidemiology of bacterial susceptibility pattern in each area.