American Journal of Oral Medicine and Radiology

COMPARISON OF ONDANSETRON V/S RAMOSETRON FOR PREVENTION OF POST OPERATIVE NAUSEA AND VOMITING IN LAPROSCOPIC SURGERIES (A STUDY OF 100 CASES)

Dipal Thakkar*, Anamika Patel, Hitesh Patel, Mukesh Shukla, Pramod, Bidyut Borah

hiteshpatel5413@gmail.com

Acute respiratory distress syndrome, Extracorporeal membrane oxygenation, Disseminated intravascular coagulation.

Postoperative nausea and vomiting (PONV) is one of the most common and distressing complications after anaesthesia and surgery, and may lead to serious postoperative complications. Patients undergoing laparoscopic surgery have been associated with high risk for developing PONV. This study was carried out on 100 patients of either sex from the age group 18-60 years of ASA risk I and II undergoing general anesthesia for various surgical procedure. Patients with history of motion sickness, past history of PONV, pregnancy , and who are menstruating, those who had received any anesthetic in last 24 hrs and body mass index >35 were excluded from the study. The patients were divided into 2 groups, classified as Group (O) inj ondansetron 4mg iv., Group (R) inj ramosetron 0.3mg iv.The drug was administered 5 min after induction in all the groups. Patients were monitored for emetic episodes, severity of nausea, requirement of rescue antiemetic and vital signs for immediate, 1 hour, 2-6 hour, 6-12 hour and 12-24 hour post-operative period that began when the patient responded to a vocal command after extubation. Metoclopramide 10mg/kg IV was given as a “rescue” antiemetic for vomiting or persistent nausea, if 2 or more episodes occurred within 24 hrs.Statistical analysis was performed with One-way analysis of variance (ANOVA) and Student‟s t-test for continuous variables with the use of EPI INFO software. Discrete variables, such as frequency of PONV and incidence of adverse effects were compared with Chi-Square test. A „p‟ value <0.05 was considered significant. Ramosetron is highly effective for prophylaxis of PONV in laparoscopic surgeries and due to its longer duration of action, single dose of Ramosetron is highly effective for prevention of PONV up to 24 hrs postoperatively.