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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
FORMULATION OF FAST DISINTEGRATING AMOXICILLIN AND POTASSIUM CLAVULANATE TABLETS: IN-VITRO EVALUATION AND STABILITY STUDIES
Author
Subbaiah S*, Karuna DS, Grace Rathnam and Ubaidulla U
Email
karunaspharma@gmail.com
keyword
Amoxicillin, Potassium Clavulunate, Dispersible tablet, Sodium Starch glycolate.
Abstract
The present work is aimed to develop a stable formulation of preferred combination of two antibiotics-Amoxicillin and Potassium Clavulunate by using various disintegrants. Amoxicillin and Potassium Clavulunate dispersible tablets were prepared by direct compression method using different disintegrants i.e. Croscarmellose sodium, Crosspovidone, Maize starch and Sodium Starch Glycolate. Aspartame as a sweetener and strawberry flavor were used to increase palatability. The Powder blends were subject to various physical characteristics test such as bulk density, tapped density, Hausner’s ratio and Compressibility Index. The prepared tablets were evaluated for hardness, friability, Disintegration time and Wetting time and In vitro drug release. Amoxicillin and Potassium Clavulunate dispersible tablets were found to be of good quality fulfilling all the requirements for dispersible tablets. The results indicated that concentration of Crosspovidone, Croscarmellose sodium, Sodium starch glycolate and maize starch significantly affected the release property of the drug. Croscarmellose sodium showed high disintegration time as compared to batches prepared from Maize starch, Sodium starch Glycolate and Crosspovidone. The In-vitro dissolution profile of F8 using Crosscarmellose sodium (15%) was found better than all other formulations. The optimized batch tablets were packed in ALU-ALU pack and performed stability studies at 40°C/75%RH. There is no change in the physiochemical properties of the tablet during the stability period. Hence the developed dispersible tablet could be found suitable alternate dosage form.
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