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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
COMPARISON OF SERUM CREATININE AND SERUM CYSTATIN C IN DIABETIC NEPHROPATHY
Author
Gaffar Sarwar Zaman
Email
drgszaman@gmail.com
keyword
Serum Creatinine, cystatin C, nephropathy, diabetes mellitus.
Abstract
Serum Creatinine estimation is dependent upon various factors and hence not an accurate marker of renal function. Recently Serum Cystatin C estimation is found to be comparable with Serum Creatinine estimation as a marker of renal function. But its use in diabetic nephropathy is still inconclusive. Two groups, one with long-standing non-insulin-dependent diabetes mellitus (type II), and one control, each containing 40 cases, were considered for the study. A significant increase of all the measured parameters in comparison to the control group, was observed. A more significant increase (p<0.001) was observed in cystatin C than in Serum creatinine (p<0.05). The present study demonstrated that determination of serum cystatin C might be useful in the detection of incipient diabetic nephropathy and is a potentially better marker than creatinine during advanced diabetes mellitus type 2.
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