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European Journal of Pharmaceutical Science and Research

Volume 2, Issue 1, 2015
Mcmed International
European Journal of Pharmaceutical Science and Research
Issn
XXX-XXXX (Print), XXXX-XXXX (Online)
Frequency
bi-annual
Email
editorejpsr@mcmed.us
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Abstract
Title
FORMULATION AND EVALUATION OF NIZATIDINE MUCOADHESIVE MICROSPHERES BY IONIC-GELATION METHOD
Author
Kameswararao Sankula*, Saieswar Kota, Srinath Nissankar Rao
Email
brahmaiahmph@gmail.com
keyword
Abstract
The present study involves preparation and characterization of mucoadhesive microspheres with Nizatidine as model drug for prolongation of gastric residence time. Mucoadhesive formulation has been accepted as a process to achieve controlled release and drug targeting. Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres exhibited a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The microspheres were prepared by Orifice Ionic-Gelation method using mucoadhesive polymers like HPMC K100 (hydroxy propyl methyl cellulose), CMC (carboxy methyl cellulose) , Carbopol 934 and a release controlling polymer Sodium alginate by using Calcium chloride(4%w/v) as curing agent. In Vitro drug release studies were performed and drug released was evaluated. The effect of polymer concentration on size of microspheres and drug release were observed. The prepared microspheres exhibited prolonged drug release the mean particle size increased as the concentration of copolymer increased, as the carbopol polymer concentration increases the mucoadhesion increased and the drug release rate decreased at higher concentration of HPMC K100. Key words: Nizatidine, Microspheres, Microencapsulation, Mucoadhesion, Ionic gelation, HPMC.
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