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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
FETOTOXICITY OF TREATED SLUDGE FROM CETP, PALI (INDIA) IN SWISS ALBINO MICE: A MULTIGENERATIONAL STUDY
Author
Himani Tiwari
Email
dr.himanitiwari@gmail.com
keyword
Leachate, Feto-Toxicity, Prepartum, Postpartum, Lacrimation.
Abstract
Water is a precious commodity and very essential part of all lives on earth. Unfortunately, it is polluted through the uncontrolled and indiscriminate discharge of pollutants from domestic, commercial and industrial sources. This is visible everywhere and the water pollution problem is progressively mounting in our country. An attempt has been made to compare the fetotoxic effect of sludge leachate administered during two generations. Here the leachate obtained is from CETP, Pali which receives effluent exclusively from textile and dyeing industries, is diluted with water according to low level exposure dose concentration of 1/1000 and then administered to Swiss albino mice along with control group receiving simple tap water for consecutive three generations in order to access the long term effect of leachate. Research finding revealed that the treated sludge leachate from CETP, Pali at the tested dose level produced fetotoxicity to certain extent at both the generations. It was evident by significant reduction in body weight gain, substantial loss of body fur and restlessness. Visceral malformation included abnormalities in eye (like anophthalmia, microphthalmia), pulmonary edema, reduced gonadal size in dose related manner. Skeletal malformation included poor ossification of skull bones, Sternal defects, rib anomalies in all the fetuses of dose group followed by reduction in body weight gain during both prepartum and postpartum period, substantial loss of body fur and restlessness in F1 generation. No second generation was observed indicating the potential toxicity of leachate and ability to accumulate and persist inside the body.
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