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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
ACINETOBACTER: NO MORE A CHOISY INTRUDER IN NEONATAL SEPSIS
Author
*1Deepa S, 2Archana Rao K, 3Venkatesha D
Email
drdeepa_intel@yahoo.co.in
keyword
Acinetobacter, Neonatal septicemia, Multi drug resistance, Mortality.
Abstract
The bacteriological profile of neonatal sepsis is constantly under change with advances in the early diagnosis and treatment of sepsis.Pan-resistant Acinetobacter infection has emerged as an important nosocomial pathogen in the inpatient neonates over the past few years. The primary objective of this study was to find out the prevalence of Acinetobacter species in cases of neonatal septicemia and their antimicrobial susceptibility pattern. This is a prospective study done over a period of one year at Mysore Medical College and Research institute, Mysore, Karnataka, India. Inclusion criteria were neonatal sepsis cases, where Acinetobacter species were isolated from blood cultures. In present study incidence of Acinetobacter infection is 6.9%. Antimicrobial susceptibility test showed that 78 isolates were resistant to Ampicillin and Amoxyclav (97.5%).78 (98%) isolates showed multi drug resistance (resistance to ≥ 3 categories of antibiotics), 25(31%) were sensitive to only one antibiotic, 17(21%) were sensitive to only two antibiotics, pan drug resistance was seen 12 (15%) of isolates. Susceptibility to Piperecillin-tazobactem was maximum 68 (85%) followed by Imipenem 60 (75%). Metallobeta lactamase producing strains were detected in 7(8%) isolates. Multidrug resistant Acinetobacter infection is fatal, particularly in premature and low birth weight neonates. Therefore, an effective infection control policy and rational antibiotic use are mandatory in neonatal intensive care areas of each hospital in order to control Acinetobacter infection and improve outcome.
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