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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
TRIANTHEMA DECANDRA (L.): A NEPHROPROTECTOR DURING GENTAMICIN-INDUCED NEPHROTOXICITY IN MALE WISTAR RATS
Author
Ganapathy Sindhu*, Ramalingam Sharmila, Emayavaramban Nishanthi, Annamalai Vijayalakshmi, Gopalakrishnan Tamizharasi
Email
ganapathysindhu@gmail.com
keyword
Gentamicin, Nephrotoxicity, Trianthema decandra, Oxidative stress, Renal function markers.
Abstract
The purpose of this study was to evaluate the nephroprotective effect of Trianthema decandra (L.) on gentamicin induced nephrotoxicity in male Wistar rats. Methods: Gentamicin (80 mg/kg, b.w., i.p) was administered for 8 days to induce toxicity in the toxic group. The ethanol extract of the roots of Trianthema decandra (L.) (150mg/kg and 300 mg/kg) was administered orally to treatment groups rats for 3 days before gentamicin treatment and thereafter with gentamicin for 8 days. Gentamicin alone treated rats shown significant increases in urea, creatinine, uric acid, thiobarbituric acid reactive substances, followed by a significant reduction in glutathione peroxidase, superoxide dismutase, catalase, and reduced glutathione in plasma, liver and kidney tissues. Further, gentamicin induced nephrotoxicity was evidenced through renal histological examination as tubular necrosis. Trianthema decandra (L.) pretreatment altered the antioxidant status and significantly reversed the levels to near normal. Histopathological changes were in accordance with the biochemical findings. The results show that the root extract of Trianthema decandra (L.) with the presence of natural antioxidants, bioflavanoids, and other bioactive compounds scavenged the free radicals generated by gentamicin and ameliorated the severity of gentamicin induced nephrotoxicity by enhancing the antioxidant system and protecting the cellular integrity of kidney tissues. In conclusion, the present study provides the corroborative scientific evidence for the folklore use of Trianthema decandra (L.) in urinary troubles.
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