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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EVALUATION OF RAPID IMMUNO-CHROMATOGRAPHY TEST AND ENZYME LINKED IMMUNO-SORBENT ASSAY FOR DETECTION OF DENGUE NS1 ANTIGEN IN CLINICALLY SUSPECTED DENGUE CASES AT A TERTIARY CARE HOSPITAL
Author
1* Narayan Shrihari, 2Krishna S and 3Ramakrishna K
Email
shriharimicro@gmail.com
keyword
Dengue infection, Rapid immuno-chromatography test (Rapid ICT) and enzyme linked immuno-sorbent assay (ELISA).
Abstract
Background: Rapid diagnosis of Dengue virus infection is essential for the patient management. The rapid immuno-chromatography test (Rapid ICT) and enzyme linked immuno-sorbent assay (ELISA) for dengue NS1 antigen. ELISA is giving more accurate result as compared to Rapid ICT. Objective: To evaluate and compare rapid ICT and ELISA for dengue virus infection. Material and Methods: The laboratory records of clinically suspected dengue patients from January to August 2014 were analyzed retrospectively and results of NS1 antigen of dengue virus tested by rapid ICT and ELISA respectively and we compared the accuracy of both the tests. Both the rapid ICT and ELISA tests were performed by following the manufacturer’s instructions. Result: ELISA showed excellent sensitivity as compared to rapid ICT. The rapid test detected NS1 antigen and 258 serum samples were positive out of 1106(23.33%).ELISA test detected NS1 antigen and 146 serum samples were positive out of 258(56.59%).The present study emphasizes the continuous sero-epidemiological surveillance for the effective dengue virus infection control programme. Conclusion: These tests should be a useful aid in confirming the clinical diagnosis of dengue virus infection. The rapid test will be particularly valuable in peripheral health setting while the ELISA has a place in central testing Laboratories.
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