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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
MOLECULAR DOCKING STUDIES OF XANTHINE OXIDASE INHIBITORS IDENTIFIED FROM PSEUDARTHRIA VISCIDA
Author
Thinagaran Rajan1* and Suriyavathana Muthukrishnan2
Email
drrajan2012@gmail.com
keyword
Abstract
The enzyme xanthine oxidase catalyses the oxidation of hypoxanthine and xanthine to uric acid, which plays a crucial role in gout. During the reoxidation of xanthine oxidase, molecular oxygen acts as electron acceptor, producing superoxide radical and hydrogen peroxide. Gouty arthritis is an acute rheumatoid disorder that occurs in connection with the deposit of monosodium urate crystals in the joints. Monosodium urate crystal-induced inflammation is triggered by infiltration of neutrophils, and subsequent production of damage-causing superoxide. Bioinformatics is seen as an emerging field with the potential to significantly improve how drugs are found brought to clinical trials and eventually released to the marketplace. Computer Aided Drug Design (CADD) is a specialised discipline that uses computational methods to stimulate drug-protein interaction. Discovery studio 2.1 provides a set of protocols for predicting and analysing the interaction between protein and ligands. Molecular docking experiments were carried out for compounds identified from Pseudarthria viscida root extract with Xanthine oxidase using Accelry’s Discovery Studio 2.1. Out of thirteen compounds characterized from Pseudarthria viscida root, six compounds docked with Xanthine oxidase. Of that, n-Hexadecanoic acid and Tetradecanoic acid can be considered as a lead compound to treat hyperuricemia. Key words: Xanthine, Hyperuricemia, Pseudarthria viscida.
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