International Journal of Advances In Case Reports

A COMPREHENSIVE REVIEW ON POLYCYSTIC OVARY SYNDROME AND ITS THERAPEUTIC MANAGEMENT FOR OVULATION INDUCTION IN INFERTILE WOMEN- PART-I

sasisasikala2007@rediffmail.com

SasikalaM1*, Parthiban P1, Vijayakumar S2

Rotterdam, Anovulation, Cyst, Women, Endocrine, and obesity.

Polycystic ovarian (PCO) disease or Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects 6-8% of women. It is characterized by infrequent ovulation or anovulation, high androgen levels in the blood, and the presence of multiple persistent ovarian cysts. The objective of this study was to perform a comprehensive review of the literature to determine therapeutic management for ovulation induction in infertile women of polycystic ovary syndrome. Literature search was performed in November 2013 in the following electronic databases: Medline, Ebsco, Pubmed, Dove Press and the Cochrane Library. We performed a search over the period December 1980 to May 2014 and only PCOS were included. Search terms were as follows; Based on Rotterdam Criteria, Insulin resistance, Polycystic ovary syndrome. Further relevant papers were located by hand-searching the reference lists of recent reviews and original articles. Only human studies were included. The results of PCOS has serious health consequences, abnormal glucose tolerance, hypertension, obestiy, ovariantheca cells, type 2 diabetes and dyslipidemia. During pregnancy, these women have an increased risk of spontaneous abortion and gestational diabetes . Hyperinsulinaemia, the consequence of insulin resistance, stimulates both ovarian and adrenal androgen secretion and suppresses sex hormone-binding globulin synthesis from the liver, resulting in an increase in free, biologically active androgens. Based on available data in the literature, authors conclude that, PCOS is a complex disorder, in multiple genetic, metabolic and hormonal controls fails to interact properly, however, interdisciplinary approach needed to manage the symptoms of the disease.