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Acta Biomedica Scientia

Volume 13, Issue 1, 2026
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
IN-SILICO EVALUATION OF GLYCYRRHIZA GLABRA DERIVATIVES AS POTENTIAL ANTIVIRAL AGENTS AGAINST INFLUENZA
Author
Dr. Vijayalakshmi N, Nagendra Babu Battula, Veena K, Levaku Pranathi
Email
nagendrababu29@gmail.com
keyword
Influenza, Glycyrrhiza glabra, Molecular docking, Liquiritigenin and Antiviral agents
Abstract
Influenza is a significant respiratory disease and seasonal outbreaks of the disease have a serious impact of morbidity and mortality across the globe. Although vaccines and antiviral drugs such as oseltamivir are available, the virus rapidly mutates making it difficult to treat it. The antiviral activity of natural products derived by Glycyrrhiza glabra (licorice), i.e. Liquiritigenin, Glabridin and Oseltamivir, was evaluated on the basis of in-silico molecular docking towards MORC3 CW domain Influenza NS1 peptide (PDB ID: 6O5W) in the present research. It was found that Docking simulations show that Liquiritigenin had the most favorable binding affinity with lowest MolDock score of -65.27, then the next is Glabridin and Oseltamivir. These findings imply that Liquiritigenin and Glabridin can be considered as promising antiviruses to be developed in the future. The results affirm the possible role of Glycyrrhiza glabra extracts as an adjunct to influenza, which can be further experimentalized
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