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European journal of molecular biology and biochemistry

Volume 12, Issue 1, 2025
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
IN SILICO EVALUATION OF TERMINALIA CHEBULA PHYTOCONSTITUENTS AS POTENTIAL ANTIFUNGAL AGENTS AGAINST CANDIDA ALBICANS
Author
Dr. Vijayalakshmi N, Nagendra Babu Battula2, Veena K, Levaku Pranathi
Email
Vijayaotri@gmail.com
keyword
Candida albicans, Terminalia chebula, Molecular Docking, Antifungal Agents and Als3 Adhesin
Abstract
Candida albicans is the cause of candidiasis, which is one of the most significant fungal infections, with the potential to cause severe complications, particularly in immunocompromised people. The growing resistance of antifungals highlights the use of alternative therapies. The paper explores the antifungal effects of chebulic acid, gallic acid and ellagic acid, which are antimicrobial agents of Terminalia chebula, against Als3 adhesin of C. albicans (PDB ID: 4LEB) through the simulation of molecular docking. The findings demonstrated that the chebulic acid had the strongest binding affinity and hydrogen bonding reaction, next was fluconazole, a common antifungal. The results indicate that chebulic acid is more stable in interaction and thus it is a promising agent in the treatment of systemic candidiasis. This research gives credit to the prospects of natural compounds in augmenting antifungal treatment and eliminating drug-resistant strains
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