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Acta Biomedica Scientia

Volume 6, Issue 3, 2019
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
NON-DIABETIC HYPERTENSIVE PATIENTS TREATED WITH LOSARTAN AND ATENOLOL: EFFECT ON INSULIN SENSITIVITY
Author
Dr.Aadil Ashraf1 and Dr. Kumarasingam
Email
keyword
Losartan, Atenolol, Insulin, Hypertensive Patients
Abstract
The research examined the changes in glucometabolic parameters after treating nondiabetic hypertensive patients with losartan and atenolol. Using a prospective, open-label, parallel-group study, patients without diabetes and mild to moderate hypertension were randomly assigned to receive either losartan (titrated from 50 to 100 mg/day, n = 40) or atenolol (titrated from 25 to 100 mg/day, n = 40) for 24 weeks. The following were measured at baseline, 12 weeks and 24 weeks: FPG, FPI, HOMA-IR, lipid parameters and average systolic and diastolic blood pressure. At the end of the study, losartan caused a substantial drop (P < 0.05) in FPG, FPI and HOMA-IR compared to atenolol and the beginning of the study. Similarly, atenolol was associated with an increased value of HOMA-IR compared to when ADRP was given. This study suggests that insulin sensitivity is increased with losartan, whereas atenolol reduces this sensitivity. That is why losartan is more effective than atenolol when it comes to glucose-insulin metabolism
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