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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
TO STUDY ALLERGIC MUCIN IN ALLERGIC FUNGAL RHINOSINUSITIS IN SOUTH INDIA
Author
Lakshmi Narasimha Rao, Hari Prasad B
Email
drvrvkk@gmail.com
keyword
Assistant Professor of ENT, Sree Balaji Medical College & Hospital, Chennai, Tamil Nadu, India. 2 Associate Professor of ENT, Sri Lakshmi Narayana Institute of Medical Sciences, Pondichery, India
Abstract
Allergic fungal rhinosinusitis (AFRS) is one of the more commonly encountered forms of noninvasive fungal rhinosinusitis, seen in immune competent individuals. Allergic fungal rhinosinusitis (AFRS) is a relatively new and incompletely understood clinical entity with characteristic clinical, radiographic, and histopathologic findings. AFRS is often misdiagnosed. Recognition and understanding of this unique disease will lead to efficient diagnosis and treatment of this curable process. It is caused by a Gell and Coombs Type I, IgE mediated (and possibly Type III) hypersensitivity reaction to an extra mucosal fungal antigen. It bears striking similarities to Allergic Broncho Pulmonary Aspergillosis (ABPA), in terms of pathogenesis as well as treatment. It commonly presents as nasal polyposis. Most current treatment protocols for this condition are based on a combined medical and surgical approach. This is a single-centre prospective study, undertaken to determine the incidence of allergic mucin in patients with AFRS, and its role in the outcome after treatment with systemic anti-fungals and steroids. In this article we have recapitulated the history, epidemiology, etiology, clinical features, diagnostic investigations and treatment protocols for this disease. AFRS is a unique disease process that differs from other forms of sinusitis and as such requires that physicians understand its diagnosis and management to provide care for patients with this condition.
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