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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
ENHANCEMENT OF SOLUBILITY OF NITRENDIPINE BY SOLID DISPERSION TECHNIQUE
Author
Vinod M Thakare*1, Sonal D Patil1, Bharat W Tekade1, Kundan P Chaudhari1, Umesh T Jadhao1, Vijay R Patil1, Rajendra P Zope2
Email
vmthakre@gmail.com
keyword
Nitrendipine, Solid dispersion, Poly vinyl Alcohol, Polaxamer, Solubility.
Abstract
In present study PVA and Poloxamer188 are selected as carrier because of their chemical and pharmaceutical inertness. Solubility behavior of Active pharmaceutical ingredient is one of the most challenging aspects in the formulation development. Nitrendipine is a dehydropyridine calcium antagonist widely used as antihypertensive and antianginal drug but having very low aqueous solubility.The dissolution rate of nitrendipine by solid dispersion was enhanced significantly with increasing the amount of dispersing agents. PVA and Poloxamer188 by virtue of their water solubility may lead to an increase in degree of solubility of poorly water-soluble drug.
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