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American Journal of Biological and Pharmaceutical Research

Volume 12, Issue 1, 2025
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF TORSEMIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Author
Mohammad Neha Chandini* Rajitha S
Email
keyword
RP-HPLC, Torsemide, Pharmaceutical Analysis, ICH Guidelines.
Abstract
Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) is employed in this study to develop a method for estimating Torsemide in tablet dosage forms that is accurate and reliable. The quality control of pharmaceutical preparations of torsemide, a loop diuretic commonly prescribed for the treatment of edema and hypertension, requires precise analytical methods. An optimized mobile phase of acetonitrile and water in specific proportions was used to achieve chromatographic separation, monitored at an optimal UV detection wavelength using a C18 column. Validation of the method was conducted in accordance with International Conference on Harmonisation (ICH) guidelines, including assessment of parameters such as specificity, linearity, accuracy, precision, and robustness
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