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Acta Biomedica Scientia

Volume 11, Issue 2, 2024
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
SIMULTANEOUES ESTIMATIION OF IRBESARTAN AND HYDROCHLORTHIAZIDE BY RP –HPLC METHOD
Author
Esnapalli Vineetha*, Deepthi P
Email
keyword
Irbesartan, Hydrochlorothiazide, RP-HPLC, Validation, Pharmaceutical Dosage Form
Abstract
A reliable Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method was used in this study to estimate both Irbesartan and Hydrochlorothiazide simultaneously. A C18 column was used for efficient separation, with a buffer and organic solvent in an appropriate ratio as the mobile phase. Validation followed ICH Q2(R1) guidelines to ensure accuracy, precision, specificity, linearity, robustness, and system suitability. Across both Irbesartan and Hydrochlorothiazide's concentration ranges, the developed method showed excellent linearity. Recoveries confirmed the method's accuracy, and precision studies demonstrated its reproducibility. Hydrochlorothiazide and Irbesartan in combined dosage forms can be routinely analyzed with this validated RP-HPLC method
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