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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
ROLE OF CS21 PILI IN ENTEROTOXIGENIC ESCHERICHIA COLI (ETEC) PATHOGENESIS: MECHANISMS OF ADHESION AND VIRULENCE IN IN VITRO AND IN VIVO MODELS
Author
Dr. Srinidhi B.V
Email
keyword
ETEC, CS21 pili, enterotoxigenic E. coli, intestinal colonization, bacterial adhesion.
Abstract
Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease, particularly affecting travelers and infants in developing regions. One of its key virulence factors, CS21 type IV pili, facilitates intestinal colonization, adhesion, and microcolony formation. However, the precise role of CS21 in ETEC pathogenesis remains unclear. This study explores CS21-mediated adhesion mechanisms using in vitro epithelial cell models (IPEC-J2 and IPEC-1) and in vivo neonatal mouse models. Quantitative adhesion assays demonstrated that CS21-expressing ETEC strains adhered significantly more than CS21- deficient mutants, with adhesion being inhibited by anti-LngA monoclonal antibodies and neuraminidase treatment. Furthermore, CS21-expressing ETEC strains exhibited increased virulence in neonatal mice, reinforcing their role in gut colonization and pathogenicity. These findings highlight CS21 as a critical virulence factor, offering potential targets for novel therapeutic interventions to mitigate ETEC-related infections
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