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Acta Biomedica Scientia

Volume 11, Issue 2, 2024
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EVALUATING THE SURGICAL PLETH INDEX (SPI) AS A TOOL FOR MONITORING NOCICEPTION AND INTRAOPERATIVE STRESS DURING GENERAL ANAESTHESIA
Author
Dr. Dinesh Kumar Gontla V
Email
keyword
Surgical Pleth Index, nociception, intraoperative stress, general anaesthesia, stress hormones.
Abstract
This study investigates the Surgical Pleth Index (SPI) as a tool for assessing nociception and intraoperative stress during general anaesthesia. We observed moderate-to-strong correlations between SPI and stress hormones (ACTH, cortisol, epinephrine, and norepinephrine) during key intraoperative events, including intubation, peak stress, and post-peak stress, with SPI accurately predicting ACTH levels. SPI outperformed traditional indicators such as blood pressure, heart rate, and BIS in detecting nociceptive stimulation, highlighting its potential for more accurate and consistent intraoperative monitoring. The stress response, triggered by the activation of the hypothalamus-pituitary-adrenal (HPA) axis during surgery, influenced the secretion of cortisol and ACTH, while epinephrine and norepinephrine levels remained stable. The study emphasizes the potential of SPI for optimizing nociception monitoring and improving anaesthesia management. Future studies with a broader range of surgical procedures are needed to refine SPI’s application in clinical practice
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