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American Journal of Oral Medicine and Radiology

Volume 8, Issue 2, 2021
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
ROLE OF HMGB1 IN INFLAMMATION AND EOSINOPHIL INFILTRATION IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS
Author
Suresh Babu
Email
keyword
Chronic Rhinosinusitis,Nasal Polyps,HMGB1,Eosinophils,Inflammation
Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition that involves an exaggerated immune response, often characterized by eosinophilic infiltration. This study aimed to explore the role of High Mobility Group Box 1 (HMGB1), a nuclear protein implicated in inflammation, in the pathogenesis of CRSwNP. Tissue samples from 50 patients with CRSwNP, along with healthy controls, were analyzed for HMGB1 expression using immunohistochemistry. The findings revealed distinct HMGB1 expression patterns, with significant differences between eosinophilic and non-eosinophilic CRSwNP patients. Notably, HMGB1 expression was elevated in the inflammatory cells, particularly in non-eosinophilic cases, suggesting its key role in the inflammatory cascade. The study underscores the potential of HMGB1 as a target for future therapeutic strategies in managing CRSwNP. Moreover, the results highlight the complex interplay between immune cells, inflammatory mediators, and the epithelial barrier in chronic sinusitis.
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