Acta Biomedica Scientia

ASCETIC FLUID CHOLESTEROL AND SERUM ALBUMIN IN DIFFERENTIAL VALUES OF ASCITES AND ITS DIAGNOSIS IN INDIANS

Lakshmi Tilak S1*, Prabhakar Reddy E

drpebyreddy@gmail.com

Mental Ascites, Nephrosis, Inflammation, Portal hypertension, Adenosine deaminase

Ascites is determined as presences of pathological changes in peritoneal cavity. It’s mainly accumulation of free fluid. In prospective study ascitic fluid cholesterol levels in various types of ascites, to compare diagnostic values of ascitic fluid cholesterol levels v/s SAAG, to study SAAG in various types of ascites. To find out specificity & sensitivity of ascitic fluid cholesterol levels in differential diagnosis of ascites.The study was conducted on 100 patients of ascites of different etiologies admitted in Sri Lakshmi Narayana Institute of Medical Sciences of 15-65 years of either sex. The following study groups were made viz.: - Group A 29 Cases of ascites caused by cirrhosis of liver, Group B 30 cases of ascites caused by Tuberculosis, Group C 25 cases of ascites caused by Malignancies, Group D, E, F25 cases of ascites caused by others (e.g. CHF, CRF, Nephrotic Syndrome, Anemia-hypoproteinemia, Bacterial Peritonitis, etc. The paracentesis was performed after proper positioning of patient .150 ml. of ascitic fluid was drawn and examined for, total protein, albumin, adenosine deaminase (ADA) (when indicated), sugar, cholesterol, total cell count, cell type, malignant cells, microbiological tests (AFB stain , Gram staining, aerobic and anaerobic culture, sputum culture,) Liver function test, Serum cholesterol, Sputum for AFB and culture (When indicated), ECG, Chest X-ray, X-ray abdomen, Ultrasonography of abdomen: Histopathological examination. Exclusion Criteria- Hemodynamically unstable patients: Arterial hypotension and bleeding abnormality. Ascitic fluid cholesterol is an effortless, despicable and consistent biochemical parameter to differentiate (cirrotic) transudative and other ascites from malignant ascites. It is not useful in differentiating transudative cirrhotic from other tubercular ascites