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European journal of molecular biology and biochemistry

Volume 11, Issue 1, 2024
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
IRON METABOLISM IN CHRONIC LIVER DISEASE: EVALUATING IRON PROFILE ALTERATIONS AND THEIR CORRELATION WITH DISEASE SEVERITY
Author
Dr. Sunkam Vanaja*
Email
keyword
Chronic Liver Disease, Iron Metabolism, Ferritin, Child-Pugh Score, Liver Dysfunction. ABSTRACT Chronic Liver Disease (CLD) is a progressive condition associated with significant alterations in iron metabolism, manifesting as either iron deficiency
Abstract
Chronic Liver Disease (CLD) is a progressive condition associated with significant alterations in iron metabolism, manifesting as either iron deficiency or iron overload. This study aimed to evaluate the iron profile and its correlation with disease severity in 150 CLD patients at Katuri Medical College and Hospital, Guntur, Andhra Pradesh, India. Iron profile parameters, including serum iron, ferritin, total iron-binding capacity (TIBC), and unsaturated iron-binding capacity (UIBC), were analyzed. Results indicated that 40.0% of patients had below-normal serum iron levels, while 50.0% exhibited elevated ferritin levels, reflecting iron overload and inflammatory activity. TIBC and UIBC were abnormal in a significant subset, indicating disrupted transferrin synthesis in advanced liver dysfunction. A strong association between altered iron parameters and disease severity was observed. The findings underscore the importance of routine iron profile evaluation in CLD management and highlight the need for personalized treatment strategies to mitigate complications
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