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American Journal of Oral Medicine and Radiology

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
MOLECULAR PATHWAYS IN PRE-ECLAMPSIA: THE ROLES OF HO, LEPTIN, COQ10, AND ESSENTIAL METALS IN MATERNAL AND FETAL HEALTH
Author
Dr. Sudipta Paul
Email
keyword
Pre-Eclampsia, Heme Oxygenase, Leptin, Coenzyme Q10, Oxidative Stress, Zinc, Copper, Iron, Hypertension, Pregnancy
Abstract
Pre-eclampsia is a pregnancy-specific hypertensive disorder that significantly impacts maternal and fetal health, leading to increased prenatal morbidity and mortality globally. This study explores the biochemical markers and molecular mechanisms implicated in pre-eclampsia, focusing on oxidative stress, inflammation, and essential mineral imbalances. Among the key elements evaluated, heme oxygenase (HO) plays a protective role by breaking down heme into carbon monoxide (CO), bilirubin, and free iron, helping to reduce oxidative stress and regulate anti-inflammatory responses. Leptin, an adipokine also produced by the placenta during pregnancy, is elevated under hypoxic conditions in pre-eclampsia, serving as a marker for placental ischemia. Additionally, Coenzyme Q10 (CoQ10) is essential for mitochondrial function and energy production, showing potential for therapeutic use due to its antihypertensive and antioxidant properties. The study also highlights the imbalance of essential metals, including zinc (Zn), copper (Cu), and iron (Fe), which are critical for enzyme function and blood pressure regulation, with an imbalance contributing to hypertension risk. Understanding these biomarkers and their functions offers insights into early detection and potential therapeutic interventions for pre-eclampsia, enhancing clinical outcomes for both mothers and infants
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