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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
TO STUDY AND IMPACT OF DESVENLAFAXINE INDUCED HISTOLOGICAL CHANGES IN PLACENTA OF SWISS ALBINO MICE
Author
Suban Mohammed Gouse1, Kannimel Helen Raju
Email
drpebyreddy@gmail.com
keyword
Serotonin, noradrenaline,syncytial knot, desvenlafaxine, gene expression, gestational period, Wistar Rat brain
Abstract
Depression during pregnancy adversely affects fetal development. Desvenlafaxine drug is used for the treatment of gestational depression. In light of the well? established role of brain?derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in regulating neurogenesis and neural survival, the role of S100b in nerve cell energetic metabolism, differentiation of neurons and glial cells, an aberrant increase in NGF, BDNF and S100b expression in the fetal brain may contribute to desvenlafaxine cognitive disorders by altering brain development. Desvenlafaxine is an antipsychotic drug categorised as dual reuptake inhibitor of serotonin & noradrenaline.It inhibits these neurotransmitters in the pre-synaptic cleft & popularly known as SNRI. During our experiment, Desvenlafaxine was given to adult swiss albino mice in the dose of 80mg per kg body wt, for first 6 days of gestation (group 2) and from gestation days 1-18 in group 3, after detection of vaginal plug which was designated as day 0 of pregnancy. Controls (group 1) were given equal amount of tap water for the entire period of gestation. Placenta of group 2, showed mild parenchymal degeneration and significantly increased number of syncytial knots. Group 3 placenta showed marked thickening and hyalinization of the basal zone. Above pathological changes and their consequent interference with fetal blood supply are suggestive of probable role of desvenlafaxine in fetal growth retardation
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