Acta Biomedica Scientia

TO STUDY BONE MARROW LESSIONS AND ITS ASSOCIATION WITH GREATER MEDIAL PROXIMAL TIBIAL SLOPE IN MIDDILE AGED WOMEN

Rashmi Kunder1*, Mohana Lakshmi T

drpebyreddy@gmail.com

Osteoarthritis, Bone Marrow Lesions (BMLs), Proximal Tibial Slope (PTS), Knee Morphology, Middle-Aged Women

Osteoarthritis (OA) is a prevalent musculoskeletal disorder characterized by articular cartilage degeneration, subchondral bone changes, and joint inflammation. Among the multifaceted factors influencing OA pathogenesis, Bone Marrow Lesions (BMLs) have become a focal point of investigation due to their association with pain, cartilage loss, and disease progression.Recent research has identified a potential connection between knee joint morphological parameters, particularly the Proximal Tibial Slope (PTS), and the development of BMLs. The medial aspect of the proximal tibia, in particular, has been implicated in biomechanical stress on the knee's medial compartment. This study aims to elucidate the association between BMLs and the Greater Medial Proximal Tibial Slope (MPTS) in middle-aged women.The focus on middle-aged women stems from the critical juncture in life when early signs of osteoarthritis often manifest. Moreover, as women are disproportionately affected by OA, they represent a crucial demographic for understanding disease dynamics. This investigation seeks to unravel the biomechanical factors contributing to BML development, particularly in the context of the MPTS. The study obtained ethical approval and involved 365 participants over a two-year period (June 2017-June 2018) at the Sri Lakshmi Narayana Institute of Medical Sciences,. Orthopaedic Ward. Inclusion criteria comprised patients aged 45- 60 with bone marrow lesions, and female patients without radiographic abnormalities, while exclusion criteria included radiographic abnormalities, rheumatoid arthritis, incomplete data, and a history of knee injury.Lifestyle habits, including drinking, smoking, and exercise frequency, were assessed through a questionnaire. General health examinations and prophylactic interventions aimed to improve average life expectancy were conducted. The study employs advanced imaging techniques and rigorous statistical analyses to comprehensively explore the relationship between BMLs and the Greater Medial Proximal Tibial Slope in middle-aged women. Anticipated findings hold promise for informing early detection and targeted interventions in osteoarthritis, contributing to enhanced patient outcomes and a deeper understanding of the intricate interplay between knee morphology and joint health.