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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
DESIGN AND DEVELOPMENT OF IMMEDIATE RELEASE ORAL SOLID DOSAGE FORM OF ADEFOVIR
Author
Jolla Rajesh, K Sandhya, Divya E, Avinash Kumar G
Email
sandhyakota1986@gmail.com
keyword
Adefovir, immediate release tablets, bioavailability, chronic hepatitis B
Abstract
Adefovir has a suboptimal bioavailability and requires formulation optimization to achieve immediate therapeutic effects. Adefovir tablets were developed and evaluated to improve its bioavailability and ensure rapid onset of action. In order to achieve optimal disintegration and dissolution profiles, the tablets were prepared by direct compression using varying concentrations of superdisintegrants. The physicochemical properties of adefovir and excipients were evaluated during the preformulation phase to ensure compatibility and stability. Physical properties of the tablets, such as hardness, friability, weight variation, and uniformity of drug content, were assessed. For the purpose of assessing the release profile of adefovir, in vitro disintegration and dissolution tests were conducted at 37°C. Tablets displayed satisfactory physical properties, including a range of hardness, friability, and uniform weight and drug content. Conclusions the immediate release tablets of adefovir developed in this study offer enhanced bioavailability and rapid drug release, potentially enhancing therapeutic efficacy in chronic hepatitis B treatment
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