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Acta Biomedica Scientia

Volume 1, Issue 2, 2013
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
DESIGN OF PVA & XANTHAN BASED HYDROGELS INCORPORATED WITH SILVER NANOPARTICLES
Author
Kanupuru Vyshnavi1, Divya E1*, Avinash Kumar G2, Pravallika
Email
divyachangaiah1806@gmail.com
keyword
Xanthan Gum, Polyvinyl Alcohol, Hydrogels, Nanosilver, Antimicrobial, Wound Healing, Biocompatibility
Abstract
Hydrogels have been widely recognized for their biocompatibility and high water content in biomedical applications. Aiming to harness nanosilver's antimicrobial properties for wound healing, this study develops and evaluates xanthan gum and polyvinyl alcohol (PVA) based hydrogels incorporating nanosilver. By freezing and thawing the hydrogels, nanosilver is distributed uniformly throughout the matrix. FTIR was used to confirm the presence of functional groups and interactions between xanthan, PVA, and nanosilver in the hydrogels. Observations of the surface morphology and distribution of nanosilver particles were conducted using scanning electron microscopy (SEM). Standard microbiological techniques were used to assess the antimicrobial efficacy of nanosilver-loaded hydrogels against common wound pathogens, including Staphylococcus aureus and Escherichia coli. Significant inhibition zones were observed in treated cultures compared to controls, indicating strong antibacterial activity. In conclusion, the xanthan/PVA hydrogels containing nanosilver show promising properties for application as antimicrobial wound dressings, because they possess both effective bacterial inhibition and favorable physical and biological properties
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