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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AND HPLC METHODS FOR SIMULTANEOUS ESTIMATION OF PROPRANOLOL HYDROCHLORIDE AND CLONAZEPAM IN TABLET DOSAGE FORMS
Author
Maneesha K.N*, Neelima B, Swapna B, Anuradha Ch, Vamsi Krishna V
Email
neelamaneeshak@gmail.com
keyword
Propranolol hydrochloride , Clonazepam , UV Spectrophotometric , High performance liquid chromatography (HPLC).
Abstract
The aim of this study was to develop and validate analytical methods, specifically UV Spectrophotometry and HighPerformance Liquid Chromatography (HPLC), for the simultaneous estimation of Propranolol Hydrochloride and Clonazepam in tablet dosage form. The focus was on using the UV Spectrophotometric method (simultaneous equation method) due to its simplicity, accuracy, precision, rapidity, and cost-effectiveness. Propranolol Hydrochloride and Clonazepam have distinct absorption maxima (? max) at 291 nm and 222 nm, respectively, allowing their simultaneous determination in a mixture. This method proves ideal for routine analysis in quality control laboratories, leveraging its practical advantages such as inexpensive reagents, solvents, and readily available instrumentation. The accuracy and precision of the method were validated through recovery and repeatability studies, highlighting its reliability for routine analytical applications
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