Acta Biomedica Scientia

TO STUDY CLINICAL PROFILE IN PATIENTS OF MEGALOBLASTIC ANEMIA ALONG WITH JAUNDICE

DR Ruplekha Goswami1, Dr Ashok Kumar T

drvrvkk@gmail.com

Megaloblastic anemia, Jaundice, Clinical profile, Hematological parameters

This study aimed to evaluate the clinical profile of patients presenting with megaloblastic anemia, with a specific focus on those concurrently manifesting jaundice. The investigation sought to provide insights into the demographic distribution, dietary habits, and various hematological and hepatic parameters among the patient cohort. A prospective study was conducted at the Department of Community and General Medicine, Tagore Medical college and Hospital,Chennai and Sree Balaji Medical college and Hospital,Chennai, encompassing a total of 50 patients diagnosed with megaloblastic anemia. These patients were further categorized based on the presence or absence of jaundice. Comprehensive data were collected, including demographic details, dietary patterns, and clinical symptoms. Hematological parameters such as hemoglobin levels, peripheral smear analysis, and liver function tests, including bilirubin and LDH levels, were meticulously documented. Among the 50 megaloblastic anemia patients, 15 exhibited jaundice, while the remaining 35 did not. The age distribution varied across different age groups, with a diverse representation of patients between 30 and 60 years. The study revealed a balanced gender distribution among those with megaloblastic anemia and jaundice. Analysis of dietary patterns highlighted a mix of strict vegetarians and those on a mixed diet, emphasizing the multifactorial nature of megaloblastic anemia. Clinical symptoms, such as glossitis, hyperpigmentation, and pallor, were universally observed, aligning with classical presentations of megaloblastic anemia. Hematological parameters reflected severe anemia in the patient cohort, with a subset displaying jaundice-associated elevations in bilirubin and LDH levels. Peripheral smear analysis consistently demonstrated characteristic features of megaloblastic anemia. This study provides a comprehensive evaluation of the clinical profile in patients with megaloblastic anemia, specifically focusing on those presenting with jaundice. The findings underscore the need for a thorough understanding of both hematological and hepatic aspects in the management of these complex cases. Future research should delve deeper into the underlying mechanisms and potential therapeutic interventions for megaloblastic anemia with jaundice