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European journal of molecular biology and biochemistry

Volume 1, Issue 5, 2014
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
EXPLORING THE PATHOGENESIS AND TREATMENT CHALLENGES OF HEMOLYTIC ANEMIA ASSOCIATED WITH GIANT CELL HEPATITIS
Author
Dr. Sateesh Chandra Jasti
Email
keyword
Giant Cell Hepatitis (GCH), Autoimmune Hemolysis, Epstein Barr virus, hepatitis B and C, Treatment Resistance.
Abstract
The pathogenesis of hemolytic anemia associated with giant cell hepatitis (GCH) in the context of autoimmune hemolysis remains elusive. A 9-month-old infant presented with fever, diarrhea, and jaundice four days prior to hospitalization. Physical examination revealed pallor, jaundice, and hepatosplenomegaly. Laboratory findings indicated elevated levels of hemolytic anemia, thrombocytopenia, immunoglobulin G (IgG), and anti-C3d antibodies. Conjugated bilirubin was measured at 84 mmol/L, with a total bilirubin of 101mmol/L. The absence of antinuclear antibodies, anti-smooth muscle antibodies, antiliver kidney microsomes 1 antibodies, and anti-endomisium antibodies, as well as negative results for Epstein Barr virus, cytomegalovirus, herpes simplex, and viral hepatitis B and C, led to the diagnosis of GCH. GCH diagnosis was supported by acute liver failure, Evan's syndrome, and positive Coomb's tests (IgG and C3). Confirmation of GCH was obtained via needle liver biopsy. Despite treatment with steroids, immune-modulatory therapy, and azathioprine, the patient succumbed to the condition
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