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Acta Biomedica Scientia

Volume 4, Issue 3, 2017
Mcmed International
Acta Biomedica Scientia
Issn
2348 - 215X (Print), 2348 - 2168 (Online)
Frequency
bi-annual
Email
editorabs@mcmed.us
Journal Home page
http://mcmed.us/journal/abs
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Abstract
Title
EFFECTIVENESS OF CYCLOPHOSPHAMIDE PULSE THERAPY IN TREATING STEROID-REFRACTORY AUTOIMMUNE HEMOLYTIC ANEMIA: A PROSPECTIVE STUDY
Author
Dr. Sateesh Chandra Jasti
Email
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Autoimmune Hemolytic Anemia, Cyclophosphamide Pulse Therapy, Steroid Refractory, Treatment Response, Hemoglobin Levels
Abstract
The management of steroid-refractory autoimmune hemolytic anemia (AIHA) poses significant challenges due to the absence of evidence-based guidelines. This study evaluated the efficacy of cyclophosphamide pulse therapy in treating severe refractory warm AIHA in a cohort of 40 patients. Hemoglobin levels, reticulocyte counts, and direct anti-globulin levels were assessed before and after cyclophosphamide treatment. Among the 28 patients who received cyclophosphamide therapy, 83% achieved partial response after 4 cycles, with only 3% showing no response. After 6 months, 47% demonstrated complete response, while 54% showed partial response. Following pulse cyclophosphamide therapy over four months, significant elevations in hemoglobin levels were observed compared to baseline, and reticulocyte levels decreased notably from the second month onwards. These findings suggest that pulse cyclophosphamide therapy yields favorable responses in patients with severe refractory warm AIHA
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